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KMID : 1039420190530040217
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Journal of Pathology and Translational Medicine
2019 Volume.53 No. 4 p.217 ~ p.224
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Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer
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An Ae-Ri
Kim Kyoung-Min
Park Ho-Sung
Jang Kyu-Yun
Moon Woo-Sung
Kang Myoung-Jae
Lee Yong-Chul
Kim Jong-Hun
Chae Han-Jung
Chung Myoung-Ja
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Abstract
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Background: Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes, and these factors are involved in carcinogenesis. 8-Hydroxydeoxyguanosine (8-OHdG) is considered to be a reliable biomarker for oxidative DNA damage. Increased levels of 8-OHdG are associated with a number of pathological conditions, including cancer. There are no reports on the expression of 8-OHdG by immunohistochemistry in non-small cell lung cancer (NSCLC).
Methods: We investigated the expression of 8-OHdG and p53 in 203 NSCLC tissues using immunohistochemistry and correlated it with clinicopathological features including smoking.
Results: The expression of 8-OHdG was observed in 83.3% of NSCLC. It was significantly correlated with a low T category, negative lymph node status, never-smoker, and longer overall survival (p < .05) by univariate analysis. But multivariate analysis revealed that 8-OHdG was not an independent prognostic factor for overall survival in NSCLC patients. The aberrant expression of p53 significantly correlated with smoking, male, squamous cell carcinoma, and Ki-67 positivity (p < .05).
Conclusions: The expression of 8-OHdG was associated with good prognostic factors. It was positively correlated with never-smokers in NSCLC, suggesting that oxidative damage of DNA cannot be explained by smoking alone and may depend on complex control mechanisms.
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KEYWORD
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Carcinoma, non-small cell lung, 8-Oxo-7-hydrodeoxyguanosine, p53, Smoking, Immunohistochemistry
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